Cambridge, UK, 26 July 2016: Axol Bioscience, a biotechnology company specialising in the supply of human induced pluripotent stem cell (iPSC)-derived cells, and Metrion Biosciences, a specialist ion channel drug discovery business, have signed a collaboration agreement to improve, standardise and more accurately predict the risk of human clinical pro-arrhythmias. This is in accordance with the FDA’s Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative, which aims to revise cardiac safety testing regulations.

Under the terms of the agreement, Metrion will use Axol’s human iPSC-derived cardiomyocytes to carry out ion channel screening, cardiac safety testing and translational phenotypic assays. Combining Metrion's contract research services and assay development capabilities with Axol’s human iPSC-derived cells and culture reagents will provide a source of well-validated, CiPA-compliant stem cell-derived assays and services for use in predictive toxicology as well as drug discovery screening.

Metrion already provides a range of services that meet some of the cardiac safety testing guidelines outlined in the CiPA paradigm, including a premium panel of human cardiac ion channel assays, providing high quality data for use in computer-based models of the human cardiac action potential to predict the risk of pro-arrhythmia. These results need to be confirmed in translational phenotypic assays, which will be carried out using Axol’s human iPSC-derived cardiomyocytes, to help ensure the results are physiologically relevant, and offer a more accurate prediction of drug liability to identify cardiac safety issues sooner and more cost-effectively.

Marc Rogers, PhD, Chief Scientific Officer of Metrion Biosciences, said: ‘The preliminary validation work we carried out using Axol Human iPSC-Derived Ventricular Cardiomyocytes show a physiological composition of the three main cardiac ion channels and appropriate cardiac pharmacology, making these cells a promising research tool for investigating CiPA liability.’

Yichen Shi, PhD, Chief Executive Officer of Axol Bioscience, said: ‘We value the insight and expertise Metrion’s team bring to this partnership. Working together we can be sure that our customers continue to get the most out of our products and services.’

Press enquiries
For Axol Bioscience:
Dr Michelle Ricketts
Axol Bioscience
T: +44 1223 751051
E: m.ricketts@axolbio.com
W: www.axolbio.com

For Metrion Biosciences:
Katie Odgaard
Zyme Communications
T: +44 (0) 7787 502 947
E: katie.odgaard@zymecommunications.com

NOTES TO EDITOR
About Axol Bioscience

Axol was co-founded by Jonathan Milner, PhD and Yichen Shi, PhD whose combined expertise and entrepreneurial spirit was the driving force behind the creation of Axol - where innovation, quality and customer service are key. Axol produces highly validated, human cells and critical reagents such as media and growth supplements. The Axol team is passionate about great science, delivering superb customer service and support and innovating future products to help customers advance their research faster. To find out more, visit www.axolbio.com

About Metrion Biosciences
Metrion Biosciences provides customers with access to a range of high quality ion channel assays on a fee-for-service or collaboration basis. Metrion Biosciences’ specialist ion channel expertise includes an industry leading panel of in vitro cardiac ion channel safety assays, translational native cell and phenotypic assays for neurological and cardiotoxicity testing, and a range of other ion channel screening services such as cell line development and optimisation. Metrion Biosciences is able to provide tailored assay formats, data analysis and reporting solutions, effective project management and quality assured data packages. www.metrionbiosciences.com


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