Genetically edited iPSC-derived models can help researchers better understand how specific genes contribute to disease pathogenesis at the molecular and cellular level in a tissue-specific nature.
Furthermore, they represent valuable platforms for identifying drug targets and studying drug mechanisms of action, paving the way for developing new therapeutic interventions for many genetic diseases that are currently untreatable. Conducted in partnership with Horizon Discovery, our custom cellular reprograming service and directed differentiation of iPSCs offers the possibility of generating many disease models from any genetic background.
By combining the power of CRISPR-Cas9 genome editing from Horizon Discovery with our iPSC technology, we can create accurate cellular models of genetic conditions by introducing disease-causing mutations into healthy control cell lines.
We can also correct those mutations in genomes of patient-derived cells to provide the matched control cell line.
What we can do for you
Our custom iPSC genome editing service includes:
✓ Optimized and highly efficient gene editing workflow for iPSCs
✓ Screening a selection of gRNAs and resulting cell clones
✓ Sequence verification of genotypes engineered:
- Homozygous and heterozygous knockouts
- Homozygous and heterozygous point mutations
- Tagged reporter cell lines
✓ Pluripotency assessment of gene-edited cell lines
Timeline
Our workflow
Let us know
Do you have any questions about our cell genome editing services?
Our dedicated Services team can help you. Our custom iPSC genome editing services can be tailored to meet your experimental requirements, helping you to save time and resources.
Your opinion matters
"I've been able to grow all the cells that Axol generated for me from my patient lines. All the cells provided grew well and I'm very happy with the service as well as the quality of the cells."
Dr David Millar, Human Molecular Genetics, Cardiff University
"Axol has provided us with more than a fast and reliable supply of functional cortical human iPSC derived neurons. It has also given us access to the collective expertise of Axol, whom we now view as much a collaborator as a company."
Dr Eric Hill, Clinical and Systems Neuroscience, Aston University
"Axol Bioscience has been a valued and important supplier to our lab’s research since the company was founded. The cells supplied to us by Axol represent exceptional value for money, but, most importantly, save us a great deal of valuable research time. Throughout our dealings with the company, service and support have always been excellent."
Dr Paul Charlesworth, Physiology, University of Cambridge
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