Custom iPSC Genome Editing

Accurate cellular models

Genetically edited iPSC-derived models can help researchers better understand how specific genes contribute to disease pathogenesis at the molecular and cellular level in a tissue-specific nature.

Furthermore, they represent valuable platforms for identifying drug targets and studying drug mechanisms of action, paving the way for developing new therapeutic interventions for many genetic diseases that are currently untreatable. Conducted in partnership with Horizon Discovery, our custom cellular reprograming service and directed differentiation of iPSCs offers the possibility of generating many disease-relevant cell types from any genetic background.

By combining the power of CRISPR-Cas9 genome editing from Horizon Discovery with our iPSC technology, we can create accurate cellular models of genetic conditions by introducing disease-causing mutations into healthy control cell lines.

We can also correct those mutations in genomes of disease-derived cells to provide the matched control cell line.

What we can do for you

Our custom iPSC genome editing service includes:

Optimized and highly efficient gene editing workflow for iPSCs
Screening a selection of gRNAs and resulting cell clones
Sequence verification of genotypes engineered:
- Homozygous and heterozygous knockouts
- Homozygous and heterozygous point mutations
- Tagged reporter cell lines
Pluripotency assessment of gene-edited cell lines

Timeline

Our workflow

Axol's iPSC Genome Editing Custom Service Timeline

Let us know

Do you have any questions about our cell differentiation services?

Our dedicated Services team can help you. Our custom iPSC genome editing services can be tailored to meet your experimental requirements, helping you to save time and resources.

Your opinion matters

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