Modeling Alzheimer’s Disease: A High Throughput-Compatible Assay for Detecting TAU Aggregation Using iPSC-Derived Cortical Neurons
Dr Alfredo Cabrera presented at SLAS 2016 a robust, scalable and disease relevant model of TAU aggregation using iPSC-derived cortical neurons that can be applied to drug discovery programs in neurodegeneration. The resulting assay is highly reproducible across users and works in different commercially available iPSC-lines, providing a reliable tool for better understanding TAU pathophysiology and the identification of novel treatments against Alzheimer’s disease.
Dr Cabrera covers the following in this presentation:
- iPSC and related initiatives in Europe: European Bank for Induced Pluripotent Stem Cells (EBiSC)
- Introduction to Alzheimer’s disease & TAU aggregation
- Modeling TAU aggregation using iPSCs
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