• Search

Modeling Alzheimer’s Disease: A High Throughput-Compatible Assay for Detecting TAU Aggregation Using iPSC-Derived Cortical Neurons

Dr Alfredo Cabrera, Janssen Pharmaceutica, presented a robust, scalable and disease relevant model of TAU aggregation using induced pluripotent stem cell (iPSC)-derived cortical neurons that can be applied to drug discovery programs in neurodegeneration. The resulting assay is highly reproducible across users and works in different commercially available iPSC-lines, providing a reliable tool for better understanding TAU pathophysiology and the identification of novel treatments against Alzheimer’s disease.

Dr Cabrera covers the following in this tutorial:

  • iPSC and related initiatives in Europe: European Bank for Induced Pluripotent Stem Cells (EBiSC)
  • Introduction to Alzheimer’s disease & TAU aggregation
  • Modelling TAU aggregation using iPSCs

Please register to watch the video or download the slides.

Modelling Alzheimer's Disease

  Please check this box to indicate that you have read and understand the privacy policy and are happy to receive emails regarding the company's products and services under those terms.