Modeling Alzheimer’s Disease: A High Throughput-Compatible Assay for Detecting TAU Aggregation Using iPSC-Derived Cortical Neurons
Dr Alfredo Cabrera, Janssen Pharmaceutica, presented a robust, scalable and disease relevant model of TAU aggregation using induced pluripotent stem cell (iPSC)-derived cortical neurons that can be applied to drug discovery programs in neurodegeneration. The resulting assay is highly reproducible across users and works in different commercially available iPSC-lines, providing a reliable tool for better understanding TAU pathophysiology and the identification of novel treatments against Alzheimer’s disease.
Dr Cabrera covers the following in this tutorial:
- iPSC and related initiatives in Europe: European Bank for Induced Pluripotent Stem Cells (EBiSC)
- Introduction to Alzheimer’s disease & TAU aggregation
- Modelling TAU aggregation using iPSCs
Please register to watch the video or download the slides.