Endothelial cells line the inside of blood vessels and play an important role in the formation and maintenance of blood vessels and vasculature. Endothelial cells have a relatively low turnover in adults since their proliferation is inhibited by contact with the capillary basement membrane. Endothelial cells can switch between quiescent and angiogenic phenotypes. During angiogenesis, endothelial cells secrete matrix metalloproteases that break down the basal lamina of the capillary. The endothelial cells migrate towards growth factors signals, such as VEGF, they proliferate and new capillary sprouts form. The vessels fuse to form a new lumen and other cell types such as smooth muscle cells and pericytes are recruited to the new capillary. Once the capillary is established, endothelial cell migration and proliferation reduces significantly. Endothelial cells regulate the exchange of nutrients between the bloodstream and surrounding tissues. There is a lot of interest in studying the role of endothelial cells in tumour growth and progression given their role in angiogenesis and remodelling the tissue microenvironment. Endothelial cells are frequently used in co-culture studies with other cell types such as cardiomyocytes given their role in cardiac development, maintenance and repair.
Human arterial endothelial cells
Human artery-specific endothelial cells from healthy, consented donors. The cells are provided at low passage so that they are physiologically relevant. The endothelial cells express von Willebrand factor and are negative for alpha smooth muscle actin. The artery endothelial cells can be passaged more than four times in our tailored Artery Endothelial Cell Culture Medium, a low serum medium that contains recombinant human growth factors that promote growth of human endothelial cells.
Human dermal microvascular endothelial cells
Human skin microvascular endothelial cells from healthy, consented donors. The dermal endothelial cells are provided at P4 and can be expanded more than four times in our Dermal Microvascular Endothelial Cell Culture Medium that contains recombinant human growth factors to promote endothelial cell growth. The endothelial cells are positive for von Willebrand factor and are negative for alpha smooth muscle actin.
Human umbilical vein endothelial cells
Human umbilical vein endothelial cells isolated from the umbilical cord of healthy, consented donors. The umbilical vein endothelial cells are provided at P1 and can be expanded more than four times in Axol Umbilical Vein Endothelial Cell Culture Medium that contains recombinant human growth factors to promote endothelial cell growth. The endothelial cells express von Willebrand factor and are negative for alpha smooth muscle actin.
Custom cell & tissue sourcing
Can't find what you're looking for? Our custom cell & tissue sourcing service can help you find primary human cells or tissue from healthy and patient donors. Simply tell us your specifications and we will endeavour to meet your requirements.Custom Cell Sourcing