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Modeling Alzheimer's disease using stem cells

Modeling Alzheimer's disease using stem cells

Dr Eric Hill, Aston University, presented his research on brain hypometabolism in Alzheimer's disease progression during Research & Innovation 2016.

Dr Hill covers the following in this presentation:

  • Brain hypometabolism is a major feature of Alzheimer's disease, appearing decades before cognitive decline and pathological lesions.
  • Human stem cell-derived neuron and astrocyte cultures treated with oligomers of amyloid beta display a clear hypometabolism, particularly with regards to utilisation of substrates such as glucose, pyruvate, lactate and glutamate.
  • As many neuronal functions, such as memory formation and protection from oxidative stress require energy formed from oxidative phosphorylation, these cells are at high risk of hypometabolism.
  • Further research using models derived from iPSCs may elucidate the mechanisms associated with amyloid beta-induced hypometabolism and therefore expedite the discovery of novel biomarkers and mechanisms associated with disease progression.

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