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Accelerated Maturation of Human iPSC-Derived Cerebral Cortical and Peripheral Sensory Neurons

Poster showing the effects of the MATURATION MAXIMIZER supplement on accelerating maturation of Human iPSC-Derived Cerebral Cortical and Peripheral Sensory Neurons


Detection of drug-induced seizure-like activities using MEA system in cultured human iPSC-derived neurons: Report from multi-site pilot study of the HESI NeuTox Committee in collaboration with CSAHi and iNCENS

Human iPSC-derived cortical neurons (Axol) and astrocytes (Axol) were cultured on 24-wells MEA plate for extracellular recording using MED64 Presto. HESI twelve compounds (pentylenetetrazole, picrotoxin, 4- aminopyrdine, linopyridine, amoxapine, strychnine, pilocarpine, amoxicillin, chlorpromazine, enoxacin, phenytoin, and acetaminophen) and dimethyl sulfoxide (DMSO) were tested at 5 concentrations for each compound (n>10).

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ICC images of iPSC-derived striatal neurons

ICC images of iPSC-derived striatal neurons showing: DARPP32, CTIP2, CALBINDIN, GABA and MAP2 staining for ax0015 and ax0018 derived striatal neurons

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Transfection of Axol Cortical Neural Stem Cells (hNSCs)

Investigation into the suitability of lipid-based transfection reagents for use with Axol Human Neural Progenitor Cells (hNPCs).

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Comparative transcriptome analysis of the expression profiles of iPS cells vs Axol human neural progenitor cells

Find the results of our comparative transcriptome analysis of the expression profiles of iPS cells vs Axol human neural progenitor cells. We provide links to the primary datasets on NCBI GEO and the summary plots of our findings.

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Study of neurite dynamics using Axol Human Neural Progenitor Cells using the IncuCyte NeuroTrack Platform

The study of neurite dynamics is elemental to the investigation of neuropathological disorders, neuronal injury and regeneration, embryonic development, and neuronal differentiation. Measurements of neurite dynamics are routinely used as a screening assay in neurotherapeutic drug discovery, and changes in neurite length and branching can predict neurotoxicity and neuroprotective effects induced by a compound.

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Application of Axol Neural Cell Culture in Multi-electrode Arrays for Studying Network Electrophysiology

Synaptic connectivity and action potential propagation were examined, in collaboration with Ole Paulsen's lab at the University of Cambridge, using MEA technology.

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Demonstration of 3D Culture of Axol hNPCs and hCCNs in a collagen gel using TAP Biosystems RAFT technology

The recapitulation of the complex microenvironment in which neural cells exists allows 3D culture systems to bridge the gap between traditional cell culture approaches and in vivo models such as transgenic mice. By mimicking the "stem cell niche" and physiological environments both mechanically and spatially, the crosstalk between the cells and environment leads to a closer scenario to what can be seen in the brain.

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Neural organoid using the Bio 3D Printer Regenova (Cyfuse Biomedical K.K.)

Currently there are no definitive therapies for CNS (central nervous system) and spinal cord injuries. The aim of a neural organoid is to overcome limitations with current therapies and provide better solutions for a damaged human CNS or a spinal cord injury. A neural organoid might also be useful in conducting a neurotoxicity test for chemical agents.

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Learn how human iPSC-derived sensory neurons can enhance your research by using an MEA system

Axol Human iPSC-Derived Sensory Neurons were cultured on a multiple-electrode array platform (Alpha MED Scientific) in order to investigate the potential of these cells to be used as an in vitro model that can recapitulate the sensation of human pain. This study showed that cultured Axol human iPSC-Derived Sensory Neurons display the typical characteristics and firing responses of human sensory neurons.


Modeling Alzheimer's disease using stem cells

Currently, the majority of studies on Alzheimer's disease have used transgenic animal models or imaging studies of the human brain. It is difficult to validate these findings using human tissue. Whilst animal models have been central to our understanding of human physiology, human stem cell-based models may help us to further our understanding of human physiology and tackle devastating diseases such as Alzheimer's disease.