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Application Note

ICC images of iPSC-derived striatal neurons

ICC images of iPSC-derived striatal neurons showing: DARPP32, CTIP2, CALBINDIN, GABA and MAP2 staining for ax0015 and ax0018 derived striatal neurons

Application Note

Transfection of Axol Cortical Neural Stem Cells (hNSCs)

Investigation into the suitability of lipid-based transfection reagents for use with Axol Human Neural Progenitor Cells (hNPCs).

Application Note

Comparative transcriptome analysis of the expression profiles of iPS cells vs Axol human neural progenitor cells

Find the results of our comparative transcriptome analysis of the expression profiles of iPS cells vs Axol human neural progenitor cells. We provide links to the primary datasets on NCBI GEO and the summary plots of our findings.

Application Note

Study of neurite dynamics using Axol Human Neural Progenitor Cells using the IncuCyte NeuroTrack Platform

The study of neurite dynamics is elemental to the investigation of neuropathological disorders, neuronal injury and regeneration, embryonic development, and neuronal differentiation. Measurements of neurite dynamics are routinely used as a screening assay in neurotherapeutic drug discovery, and changes in neurite length and branching can predict neurotoxicity and neuroprotective effects induced by a compound.

Application Note

Application of Axol Neural Cell Culture in Multi-electrode Arrays for Studying Network Electrophysiology

Synaptic connectivity and action potential propagation were examined, in collaboration with Ole Paulsen's lab at the University of Cambridge, using MEA technology.

Application Note

Demonstration of 3D Culture of Axol hNPCs and hCCNs in a collagen gel using TAP Biosystems RAFT technology

The recapitulation of the complex microenvironment in which neural cells exists allows 3D culture systems to bridge the gap between traditional cell culture approaches and in vivo models such as transgenic mice. By mimicking the "stem cell niche" and physiological environments both mechanically and spatially, the crosstalk between the cells and environment leads to a closer scenario to what can be seen in the brain.

Application Note

Neural organoid using the Bio 3D Printer Regenova (Cyfuse Biomedical K.K.)

Currently there are no definitive therapies for CNS (central nervous system) and spinal cord injuries. The aim of a neural organoid is to overcome limitations with current therapies and provide better solutions for a damaged human CNS or a spinal cord injury. A neural organoid might also be useful in conducting a neurotoxicity test for chemical agents.

Application Note

Learn how human iPSC-derived sensory neurons can enhance your research by using an MEA system

Axol Human iPSC-Derived Sensory Neurons were cultured on a multiple-electrode array platform (Alpha MED Scientific) in order to investigate the potential of these cells to be used as an in vitro model that can recapitulate the sensation of human pain. This study showed that cultured Axol human iPSC-Derived Sensory Neurons display the typical characteristics and firing responses of human sensory neurons.

Application Note

Characterization of human iPSC-Derived Microglia using live-cell imaging reveals hallmarks of morphology and function

This study characterized human iPSC-derived microglia (Axol Bioscience) using IncuCyte® Live Cell assays (Essen BioScience, part of the Sartorius Group) to validate their morphological and functional features, offering insights into their suitability for immune and neurodegenerative disease research.