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Dr Matthias Stadtfeld, Assistant Professor at the New York University School of Medicine and Dr Kejin Hu, Assistant Professor at University of Alabama at Birmingham, discussed the potential of stem cells for medical research and drug discovery.
Relevance of iPS cells in cell based screening and drug development
Drug development requires highly validated, reproducible, consistent and predictive models in order to quickly validate key targets and assess toxicity in pre-clinical assays. High quality human iPSC cells can help to that direction and Nick Clare analyses further in his presentation at ELRIG Drug Discovery 2017 how that can be achieved.
We presented 'in the field' data on our portfolio of human iPSC and primary cells demonstrating their proven ease of use, reliability and consistency as meaningful drug discovery tools. Here, we overcome the challenges of cell line variability and address the needs for cell scale-up in assay campaigns.
Toxicologists have access to a range of iPSC-derived cell types, including cardiomyocytes, hepatocytes and renal cells, used in toxicity screening. We discuss how these models are accurate and representative cell models, and how they can phase out inconsistencies and reduce the use of in vivo models.
Axol Bioscience specialize in the supply of human cell culture systems and custom services for disease modeling and drug discovery. Our expertise includes induced pluripotent stem cell (iPSC) generation, CRISPR-Cas9 gene editing, iPSC differentiation and custom cell and tissue sourcing.
We offer a variety of functionally validated human primary cells and human iPSC-derived cells from both healthy and patient donors alongside culture media and reagents that are tailored to support the optimal growth and maturation of our cells. This enables you to carry out your project in a physiologically relevant system that is not only reliable and easy to use but produces consistent results for robust replication studies.
Our team is passionate about great science, delivering superb customer service and support and innovating future products to help customers advance their research faster.
At Axol, innovation, quality and customer service are key.