The University Hospital Bern studies
the mechanisms of cancer therapy-associated cardiotoxicity, and wants to
study this in cardiomyocytes, thus they always endeavor to use the most
relevant in vitro culture systems. Therefore, they have recently
started to develop a 3D-culture model using hiPSC-derived cardiomyocytes
and have tested this system in comparison with mature primary cells.
Human iPSC-Derived Endothelial Colony Forming Cells
(ECFCs) (Axol Bioscience) are highly expandable and show comparable
expression and functionality to primary cells, providing a robust and
physiologically relevant tool for use in numerous applications. ECFCs
are rare circulating endothelial cells that display a hierarchy of
clonal proliferative potential and possess in vivo vessel-forming
ability upon implantation. In numerous animal models of disease, human
ECFCs have demonstrated the capacity to promote revascularization and
reperfusion to injured vascular beds via direct integration and/or
through paracrine effects.
Human umbilical cord blood is enriched
in circulating ECFCs compared to adult peripheral blood. We have
recently reported that ECFCs displaying properties similar to cord blood
can be obtained from human ESCs and iPSCs. Using defined serum-free
culture medium and sequential addition of specific growth factors, we’ve
identified ECFC precursors within 12 days of iPSC differentiation.
These iPSC-derived ECFCs display clonogenic proliferative potential and
in vivo vessel forming ability similar to cord blood ECFCs and promote
vascular repair and regeneration in multiple animal models of human
disease.
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