The innovation of human iPS cells has
revolutionized the field of drug discovery and
development, offering researchers access to a
consistent and almost infinite supply of stem cells
from a single donor source. Human iPSC-derived cells can offer a more
physiologically relevant model to be used for
screening candidate drugs. Human iPSC-derived renal proximal tubular cells are an example
of a new cellular development that would be ideal for use in drug discovery to identify and
predict drug induced toxicity.
The development of the first pre-validated screening
platforms for accurate prediction of nephrotoxicity in humans, and the
potential applications of these cells within drug discovery and
toxicology with progression to future kidney-on-chip technologies for
dose response prediction.
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