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Inhibitor of thymidylate synthase CAS#: 51-21-8 Citations: 1) Schlisky (1998), Biochemical and Clinical Pharmacology of 5-Fluorouracil; Oncology 12 13

Product Code: ax42428 (250 mg)

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Product Specification

Function / pharmacology 5-Fluorouracil (5-FU) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-FU are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-FU is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1
Chemical name 5-Fluoro-1H,3H-pyrimidine-2,4-dione
Molecular weight 130.08
Molecular formula C4H3FN2O2
Physical description White solid
Solubility DMSO (25 mg/ml)
Size 250 mg
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.