AKT is a serine/threonine kinase that plays an important role in multiple biological responses including metabolism, cell survival and growth by phosphorylating many proteins including GSK-3 , caspase-9, BAD, and the Forkhead Transcription Factor. AKT is activated by PI3K, which in turn can interact with FAK and other cytoskeletal-associated proteins, thereby linking activation to the cytoskeleton. AKT/PKB is constitutively active in many types of human cancer, and contributes to tumor progression by promoting angiogenesis and cell invasiveness. AKT is fully activated by phosphorylation of threonine 308 by PDK1 and serine 473 by PDK2. The reactivity of this antibody with AKT2 and AKT3 has not been tested.
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