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Amyloid (Abeta) (N-terminal)

Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.

Product Code: ax1080047 (50 µg) Categories: .

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Product Specification

Application Dot Blot|Radio Immunoassay|Enzyme Immunoassay_x000B_
Host Rabbit
Size 50 µg
Species reactivity Human
Isotype IgG
Shipping conditions Dry ice
Storage conditions -20°C