Assay-Ready Expanded (ARE) Hepatocytes, CYP2D6 Overexpressing

720.00

Assay-Ready Expanded (ARE) Hepatocytes, CYP2D6 Overexpressing (5 million cells)

Product Code: ax3702 (5,000,000 cells) Categories: .

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Description

Axol Assay-Ready Expanded (ARE) Hepatocytes are primary human hepatocytes that have been expanded in vitro so large batch sizes (up to 2000 vials) are available, ensuring a reliable and consistent source of primary hepatocytes. They are ready-to-use and should be used directly for downstream applications. ARE Hepatocytes express CYP enzymes, are metabolically functional, are polarized and can be infected by the Hepatitis C virus. The CYP2D6 Overexpressing ARE Hepatocytes are available with a matched isogenic line with basal levels of CYP2D6, permitting metabolism studies that focus on the role of CYP2D6.

ARE Hepatocyte Application Data

Metabolism, CYP induction/inhibition, Hepatotoxicity, Genotoxicity and Co-culture data 

See the Application Data

Product Specification

Donor gender Female
Donor age at sampling 9 yrs
Genetic modification Previous activation of the oncostatin M pathway
Size 5 million cells
Growth properties Adherent
Shipping conditions Dry ice
Storage conditions Liquid nitrogen
Xeno free No
Usage notes Please see our protocol for detailed instructions. Our Thawing Medium and Maintenance Medium should be used to maintain the cells in their differentiated, fully-functional state. Culture vessels must be coated with Type I Collagen (not provided).
Condition of sale The end user is not permitted to expand or re-freeze the cells

Technical Resources

References

  • Read nowLevy G, Bomze D, Heinz S. Long-term culture and expansion of primary human hepatocytes. Nature Biotechnology (2015)