Assay-Ready Expanded (ARE) Hepatocytes, CYP2D6 Overexpressing (5 million cells)
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Description
Axol Assay-Ready Expanded (ARE) Hepatocytes are primary human hepatocytes that have been expanded in vitro so large batch sizes (up to 2000 vials) are available, ensuring a reliable and consistent source of primary hepatocytes. They are ready-to-use and should be used directly for downstream applications. ARE Hepatocytes express CYP enzymes, are metabolically functional, are polarized and can be infected by the Hepatitis C virus. The CYP2D6 Overexpressing ARE Hepatocytes are available with a matched isogenic line with basal levels of CYP2D6, permitting metabolism studies that focus on the role of CYP2D6.
Product Specification
| Donor gender | Female |
| Donor age at sampling | 9 yrs |
| Genetic modification | Previous activation of the oncostatin M pathway |
| Size | 5 million cells |
| Growth properties | Adherent |
| Shipping conditions | Dry ice |
| Storage conditions | Liquid nitrogen |
| Xeno free | No |
| Usage notes | Please see our protocol for detailed instructions. Our Thawing Medium and Maintenance Medium should be used to maintain the cells in their differentiated, fully-functional state. Culture vessels must be coated with Type I Collagen (not provided). |
| Condition of sale | The end user is not permitted to expand or re-freeze the cells |
Technical Resources
References
- Read nowLevy G, Bomze D, Heinz S. Long-term culture and expansion of primary human hepatocytes. Nature Biotechnology (2015)
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