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Assay-Ready Expanded (ARE) Hepatocytes, Genotoxicity Assay Validated

Product Code: ax3703 (1,000,000 cells) Categories: .

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Description

Axol Assay-Ready Expanded (ARE) Hepatocytes are primary human hepatocytes that have been expanded in vitro so large batch sizes (up to 2000 vials) are available, ensuring a reliable and consistent source of primary hepatocytes. They are ready-to-use and should be used directly for downstream applications. ARE Hepatocytes express CYP enzymes, are metabolically functional, are polarized and can be infected by the Hepatitis C virus. Our Genotoxicity Validated ARE Hepatocytes have been functionally validated for micronucleus genotoxicity assays when used in conjunction with ARE Hepatocyte Genotoxicity Assay Medium.

Product Specification

Donor gender Female
Donor age at sampling 6 yrs
Genetic modification Previous activation of the oncostatin M pathway
Size 1 million cells
Growth properties Adherent
Shipping conditions Dry ice
Storage conditions Liquid nitrogen
Xeno free No
Usage notes Please see our protocol for detailed instructions. Our Thawing Medium should be used when thawing ARE Hepatocytes. Our Genotoxicity Assay Medium should be used to perform micronucleus assays. Culture vessels must be coated with Type I Collagen (not provided).
Condition of sale The end user is not permitted to expand or re-freeze the cells

Technical Resources

References

  • Levy G, Bomze D, Heinz S. Long-term culture and expansion of primary human hepatocytes. Nature Biotechnology (2015)