CX3C chemokine receptor 1 (CX3CR1) also known as fractalkine receptor or G-protein coupled receptor 13, is a receptor that binds the chemokine CX3CL1. CX3CR1 expression is associated with T cells, NK cells, and brain microglia. CX3CL1 is a unique transmembrane molecule with a CX3C-motif chemokine domain and a mucin-like stalk. CX3CL1 is expressed by activated-endothelial cells, neurons, and astrocytes. The interaction of CX3CR1 and its ligand mediates cell adhesion and migration. CX3CL1 has been reported to play an important role in neuroinflammation and neurodegeneration.
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