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C8-Ceramide

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Protein kinase activator CAS#: 74713-59-0 Citations: 1) Mathias et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc.Natl.Acad.Sci.USA 88 10009 2) Jarvis et al. (1993) Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc.Natl.Acad.Sci.USA 91 73 3) Upham et al. (2003), Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett., 191 27 4) Nakajima et al. (2002), Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J.Neurochem., 80 697

Product Code: ax132771 (5 mg)

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Product Specification

Function / pharmacology Cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3 Induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia in vitro.4
Chemical name N-Octanoyl-D-erythro-sphingosine
Molecular weight 425.69
Molecular formula C26 H51 N O3
Physical description White solid
Solubility DMSO (25 mg/ml) Ethanol (25 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.