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Calpain I, II (small subunit) agarose

The calpains are calcium-dependent cysteine proteases that are widely expressed in mammalian systems. Both m-calpain (calpain II) and µ-calpain (calpain I) are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca ++ requirements that are suggested by their names. Whereas m-calpain requires millimolar (mM) levels of calcium, µ-calpain is active at micromolar (µM) concentrations of Ca ++. In addition to the ubiquitously expressed m- and µcalpains, some tissue-specific calpains have been identified. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.

Product Code: ax1080377 (1 ml) Categories: .

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Product Specification

Application Immunoprecipitation
Host Mouse
Size 1 mL
Species reactivity Human
Clone number 28F3
Isotype IgG1
Shipping conditions Ambient temperature
Storage conditions -20°C