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Carnosic acid

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antioxidant CAS#: 3650-09-7 Citations: 1) Chen et al. (2012), Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis; Chem. Res. Toxicol., 25 1893 / Takahashi et al. (2009), Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism; Biochem. Biophys. Res. Commun., 382 549 / Kar et al. (2012), Carnosic acid modulates Akt/IKK/NFκB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells; Apoptosis, 17 735 / Barni et al. (2012), Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells; Oncol. Rep., 27 1041

Product Code: ax70874 (10 mg)

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Product Specification

Function / pharmacology Antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH inhibits adipocyte differentiation2. Induces apoptosis3 and inhibits the proliferation and migration of various tumor cell lines4.
Chemical name Natural diterpenoid resorcinol isolated from Rosmarinus officinalis.
Molecular weight 332.42
Molecular formula C20H28O4
Physical description Off-white or yellow solid
Solubility DMSO (50 mg/ml)
Size 10 mg
Stability Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.