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Caspase-9

Caspases are key effectors of programmed cell death. They are synthesized as inactive proenzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker which may be involved in the regulation of the different caspases. Caspase-9 is a member of the CED-3 family and bear high similarity to caspase-3. Procaspase-9 can be activated by either caspase-3 or granzyme B, although they cleave the proenzyme to different size subunits. Cleavage by granzyme B produces an active enzyme which is capable of cleaving PARP. Also, the ability of caspase-3 to activate caspase-9 seems to suggest that caspase-9 is further downstream of caspase-3 and may be involved in later changes in cells observed undergoing apoptosis.

Product Code: ax1080531 (100 µg) Categories: .

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Product Specification

Application Western Blot
Host Mouse
Size 100 µg
Species reactivity Human
Clone number LAAP6 96 2-22
Isotype IgG
Shipping conditions Ambient temperature
Storage conditions -20°C