• Search

CBR-5884

Please enquire for the latest availability and price information.

PHGDH / serine biosynthesis inhibitor CAS#: 681159-27-3 Citations: 1) Mullarky et al. (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers; Proc. Natl. Acad. Sci. USA, 113 1778 2) Snell et al. (1986) title; Trends Biochem. Sci., 11 241 3) DeNicola et al. (2015) title; Nat. Genet., 47 1475

Product Code: ax44485 (5 mg)

Payment Options

We accept Visa and MasterCard in our online store.

Worldwide Shipping

We can get your purchases to you wherever you are.

Customer Care

As an Axol customer you have access to our support team and product specialists.

Product Specification

Function / pharmacology Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.
Chemical name Ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
Molecular weight 336.39
Molecular formula C14H12N2O4S2
Physical description Off-white solid
Solubility DMSO (50 mg/ml) DMF (50 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO or DMSO may be stored at -20 for up to 2 months.