Cell Distribution: CD80 is rapidly induced on the surface of activated B cells, T cells or monocytes and is expressed at high levels on dendritic cells._x000B__x000B_Function: CD80 is one of two ligands (the other CD86) for CTLA4 and CD28. CD80 acts as co-stimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient costimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD86 in T helper cell differentiation.
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