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Cilastatin Na

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Protease inhibitor CAS#: 81129-83-1 Citations: 1) White et al. (1999), A continuous fluorometric assay for Leukotriene D4 hydrolase; Anal. Biochem., 268 245 2) Graham et al. (1987), Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-acylamino-3-substituted propenoic acids; J. Med. Chem., 30 1074 3) Keynan et al. (1995), The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA; Antimicreob. Agents Chemother., 39 1629 4) Park et al. (2016), Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer; Oncotarget, 7 9501

Product Code: ax45673 (10 mg)

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Product Specification

Function / pharmacology Dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1 Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2 Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3 Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4
Chemical name (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]-carbonyl]amino]-2-heptenoic acid, sodium salt
Molecular weight 380.43
Molecular formula C16H25N2O5S Na
Physical description White solid
Solubility DMSO (3 mg/ml) Water (35 mg/ml)
Size 10 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.