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Cinnabarinic Acid

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AhR ligand - endogenous CAS#: 606-59-7 Citations: 1) Lowe et al. (2014), Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production PLoS One, 9(2) e87877 2) Hiramatsu et al. (2008), Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymosytes through the generation of reactive oxygen species and the induction of caspase; J. Cell. Biochem., 103 42 3) Fazio et al. (2012), Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors; Mol. Pharmacol., 81 643

Product Code: ax132529 (5 mg)

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Product Specification

Function / pharmacology A novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist1. It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-221. Induces apoptosis in thymocytes2. Activates type 4 metabotropic glutamate receptors3. Counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity3.
Chemical name 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Molecular weight 300.22
Molecular formula C14H8N2O6
Physical description Red solid
Solubility DMSO (30 mg/ml) DMF (25 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.