Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors 1. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells2,3. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-24,5. The -chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-16,7. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells8. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types2. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells2,5,10. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites10,11.
We accept Visa and MasterCard in our online store.
We can get your purchases to you wherever you are.
As an Axol customer you have access to our support team and product specialists.