Human Dermal Fibroblasts isolated from a patient clinically diagnosed with Arteriovenous Malformation.
Arteriovenous Malformation (AVM) is the abnormal and irregular formation of blood vessels between arteries and veins that bypass the capillary system. These abnormal vessels can form a tangle, or nidus anywhere in the body, but become particularly dangerous if the tangles form in the brain or spinal cord. The abnormal nature of the arteriovenous connections causes a high pressure network to be directly connected to the low pressure venous system. With no pressure diffusion offered by capillaries, this puts a high amount of stress on the blood vessels. These fragile structures can cause potentially fatal bleeds such as brain haemorrhages if they become damaged or fail. The causal origin of AVM is widely debated, but it is believed to be a multifactorial disease that has a genetic link.
Here at Axol Bioscience we can offer a Reprogramming and Differentiation service, as part of our Custom Projects.
All of the cells provided are tested and are negative for HIV-1, HIV-2, Hepatitis B and Hepatitis C as detected by PCR.
The cells are confirmed to be negative for Mycoplasma and other detectable microbial contamination.