Human Dermal Fibroblasts isolated from a patient clinically diagnosed with Huntington's Disease. In these cells, one allele of the huntingtin gene (HTT) has an expansion of 56 CAG repeats and the other allele has 15 CAG repeats.
Huntington's Disease is a neurodegenerative disorder that affects motor function and co-ordination and progressively leads to dementia in the later stages of the disease. Following an autosomal dominant inheritance pattern, Huntington's Disease is characterized by Cytosine-Adenine-Guanine (CAG) repeats within the huntingtin gene. An abnormal form of the huntingtin protein is produced that affects the function and health of neurons.
The Dermal Fibroblasts can be readily cultured in their current state or reprogrammed to induced Pluripotent Stem Cells (iPSCs) and derived to a variety of other cell types. Alternatively you can purchase Human iPSC-Derived Neural Stem Cells - Huntington's Disease Patient (CAG:56) | ax0212 ready made!
Here at Axol Bioscience we can offer a Reprogramming and Differentiation service, as part of our Custom Projects. We can provide you with a variety of cells that have been derived from these Dermal Fibroblasts (Huntington's Disease) to assist with your research.
All of the cells provided are tested and are negative for HIV-1, HIV-2, Hepatitis B and Hepatitis C as detected by PCR.
The cells are confirmed to be negative for mycoplasma and other detectable microbial contamination.