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PDGFRβ inhibitor CAS#: 137206-97-4 Citations: 1) Dolle et al. (1994), 5,7-Dimethoxy-3-(4-pyridinyl)quinolone is a Potent and Selective Inhibitor of Human Vascular b-Type Platelet-Derived Growth Factor Receptor Tyrosine Kinase; J. Med. Chem., 37 2627

Product Code: ax43253 (5 mg)

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Product Specification

Function / pharmacology A potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
Chemical name 5,7-Dimethoxy-3-(4-pyridinyl)quinolone dihydrochloride
Molecular weight 339.22
Molecular formula C16H14N2O2 · 2HCl
Physical description Yellow solid
Solubility DMSO (1 mg/ml) Water (30 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.