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Epalrestat

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Aldose reductase inhibitor CAS#: 82159-09-9 Citations: 1) Kikkawa et al. (1983) Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats Diabetologica 24 290 2) Terashima et al. (1984) Effects of a new aldose reductase inhibitor on various tissues in vitro. J.Pharmacol.Exp.Ther. 229 226 3) Ramirez and Borja (2008) Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy Pharmacotherapy 28 646

Product Code: ax132837 (5 mg)

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Product Specification

Function / pharmacology Epalrestat is an aldose reductase inhibitor (IC50 = 10 nM (rat lens) and 25 nM (human placenta).1,2 It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. May be used to prevent or slow the progression of diabetic neuropathy.3
Chemical name 2-[(5Z)-5-[(E)-3-phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid
Molecular weight 319.4
Molecular formula C15H13NO3S2
Physical description Yellow solid
Solubility DMSO (5 mg/ml)
Size 5 mg
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.