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Fasudil · HCl

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ROCK inhibitor CAS#: 105628-07-7 Citations: 1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140 3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293

Product Code: ax45266 (10 mg)

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Product Specification

Function / pharmacology Rho-associated kinase inhibitor (IC50 = 1.9 µM and 10.7 µM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases.1 Reduces tryptamine-evoked vasopressor responses.2 attenuates bleomycin-induced pulmonary fibrosis in a mouse model.3 Clinically useful vasodilator.
Chemical name 1-(5-Isoquinolinesulfonyl)homopiperazine HCl
Molecular weight 327.84
Molecular formula C14H17N3O2S · HCl
Physical description White solid
Solubility DMSO (75 mg/ml) Water (100 mg/ml)
Size 10 mg
Stability Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.