G418 (also known as Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene encoding an aminoglycoside 3'-phosphotransferase, APH 3' II. G418 is commonly used in laboratory research to select genetically engineered cells. CAS Number: 49863-47-0; Synonyms: Antibiotic G 418; G418; Antibiotic G-418; BRN 1669188 Molecular Formula: C20H40N4O10; Molecular Weight: 496.558 g/mol InChI Key: BRZYSWJRSDMWLG-DJWUNRQOSA-N
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