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Recognizes a 120kDa protein, identified as the alpha subunit of hypoxia-inducible factor-1 (HIF-1). HIF-1 is a heterodimer consisting of an alpha and a beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. HIF-1 is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. HIF-1 activates transcription of hypoxia-inducible genes, including those encoding: erythropoietin, vascular endothelial growth (VEGF), heme oxygenase-1, inducible nitric oxide synthase, and the glycolytic enzymes aldolase A, enolase 1, lactate dehydrogenase A, phosphofructokinase I, and phosphoglycerate kinase 1. The C-terminal of HIF-1 alpha binds to p300. p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF.

Product Code: ax1082621 (100 µg) Categories: .

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Product Specification

Application Immunoprecipitation|Western Blot|Immunohistochemistry (Frozen & Paraffin Sections)
Host Mouse
Size 100 µg
Species reactivity Human|Sheep|Mouse|Rat|Ferret
Clone number H1alpha67
Isotype IgG2b
Shipping conditions Ambient temperature
Storage conditions -20°C