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HRP anti-Tau, 359-373

Tau protein promotes microtubule assembly and stability. Tau is abundant in neurons of the central nervous system, and is expressed at low levels in astrocytes and oligodendrocytes. Abnormal hyperphosphorylation, aggregation, and toxic gain of function of tau is associated with several neurological disorders, including Alzheimer’s disease (AD). The major building block of neurofibrillary lesions in AD brains consists of paired helical filaments (PHFs) of abnormally hyperphosphorylated tau. Six isoforms of tau are generated by alternative splicing of the MAPT gene. These isoforms are distinguished by the number of tubulin binding domains, 3 (3R) or 4 (4R), in the C-terminal of the protein and by one (1N), two (2N), or no (0N) inserts in the N-terminal domain.  Tau isoforms are differentially expressed during development.

Product Code: ax33007239 (100 µg) Categories: .

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Features & Benefits

Higly Spesific Primary Antibodies

Product Specification

Application WB
Host Rat
Specificity Tau, 359-373
Size 100 µg
Species reactivity Human, Mouse, Rat
Clonality Monoclonal
Clone number A16097B
Isotype Rat IgG2b, κ
Shipping conditions Blue ice
Storage conditions -20°C
Formulation This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.