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Human GDNF

Human GDNF

Product Code: ax139855 (10 µg) Categories: .

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Features & Benefits

GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration.

Product Specification

Size 10µg
Purity Verified by SDS-PAGE and, where possible, by RP-HPLC
Shipping conditions Ambient temperature
Storage conditions See CoA shipped with product
Source E.coli
Endotoxin level < 0.1 ng/μg of protein (< 1 EU/μg)
Reconstitution See CoA shipped with product
Stability See CoA shipped with product