Axol Human iPSC-Derived Melanocytes (African) display visible pigmentation typical morphology of proliferative melanocytes. These cells have expected marker expression of human primary melanocytes such as the transcription factor paired box 3 (PAX3) and microphthalmia associated transcription factor (MITF), along with the express of two key proteins required for melanin production tyrosinase related protein 1 (TYRP1) and premelanosome 17 (PMEL17).
Human iPSC-Derived Melanocytes are validated for purity by flow cytometry (PMEL17) and functionality (confirmation of the activation of melanin synthesis). Axol Human iPSC-Derived Melanocytes provide a relevant reliable model system perfect for research into pigmentation disorders as they are closely related to primary melanocytes.
These cells display low batch to batch variability and are available in large batch sizes making them ideal for toxicology investigations and drug discovery.