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Human iPSC-Derived Motor Neuron Progenitors (C9ORF72 expansion)

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Axol's Human iPSC-Derived Motor Neuron Progenitors from a healthy male donor carrying C9orf72 hexanucleotide expansion. The repeat expansion of the parental iPSC line of the motor neuron progenitor was determined by Southern blot.

C9orf72 is present in ~ 40% of familial ALS and 8-10 % of sporadic ALS. It is the most common mutation related to ALS - far more common than SOD1 or TDP-43.

Product Specification

Ethnicity Caucasian (Ashkenazi)
Donor mutation C9ORF72 repeat expansion
Starting material Dermal fibroblast
Donor gender Male
Donor age at sampling 62 yrs
Reprogramming method Sendai Virus
Size ≥2 million cells
Shipping conditions Dry ice
Storage conditions Liquid nitrogen

Frequently Asked Questions

You could expand the motor neuron progenitors in a T25 flask. Passage when culture reach 70% confluence, and re-plate at a density no greater than 150,000 cells/cm2. Ideal seeding density is 100,000 cells/cm2 after passaging.

Always filter the media after retinoic acid (RA) addition. Do not subject the RA aliquots to multiple freeze thaws RA is extremely light sensitive so protect the media with RA by wrapping the bottle/tube with foil.

For best results, use Surebond + Readyset for final plating.

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