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Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 M146L)

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Axol Human iPSC-Derived Neural Stem Cells

Axol Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Axol NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.

Axol NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Axol NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Axol NSCs can be maintained in culture long-term (>1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.

Product Specification

Starting material Dermal fibroblast
Donor gender Male
Donor age at sampling 53 yrs
HLA serotype A1 A3, B35(Bw6) B47(Bw4), Cw4 Cw6
Reprogramming method Episomal vector
Induction method Monolayer & chemically defined medium
Genetic modification None
Size ≥1.5 million cells
Kit components Kit includes ≥1.5M viable cryopreserved iPSC-derived Neural Stem Cells (PSEN-1 Mutation M146L) and 1 x 30 mL Neural Plating-XF Medium (ax0033).
Cell type iPSC-derived neural stem cells
Growth properties Adherent
Mutation Presenilin 1 (PSEN1) M146L
Disease information The donor (Caucasian) was clinically affected with Alzheimer's Disease.
Shipping conditions Dry ice
Storage conditions Liquid nitrogen

Technical Resources


  • Poulsen ET, Iannuzzi F, Rasmussen HF, et al., An aberrant phosphorylation of amyloid precursor protein tyrosine regulates its trafficking and the binding to the clathrin endocytic complex in neural stem cells of Alzheimer's disease patients. Journal of Frontiers in Molecular Neuroscience (2017)
  • Jones VC, Atkinson-Dell R, Verkhratsky A et al., Aberrant iPSC-derived human astrocytes in Alzheimer's disease. Cell Death and Disease (2017)