Human iPSC-Derived Neural Stem Cells - Huntington's Disease Patient (CAG:56)

560.00

Human iPSC-Derived Neural Stem Cells - Huntington's Disease Patient (CAG:56). 1 vial of Neural Stem Cells (1.5 million cells/vial) and 1 bottle of Neural Plating-XF Medium (30 mL). 

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Model Huntington's Disease in a Dish

We have applied our innovative technology to differentiate human neural stem cells from iPSCs derived from a patient clinically diagnosed with Huntington’s Disease. In these cells, one allele of the huntingtin gene (HTT) has an expansion of 56 CAG repeats and the other allele has 15 CAG repeats. Our cells allow Huntington's Disease researchers to build their own human cellular models in a disease-relevant genetic and cellular context.

Whether you study Huntington's Disease pathogenesis at the cellular level, perform neurotoxicity testing or pre-clinical drug screening, we believe that Axol Huntington's Disease patient-specific NSCs, along with our optimized culture reagents, provide the perfect culture system for your research success.

Axol Human iPSC-Derived Neural Stem Cells

Axol Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Axol NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.
Axol NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Axol NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Axol NSCs can be maintained in culture long-term (>1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.

Click here to see the data on Axol Neural Stem Cells
Starting material Fibroblasts
Donor gender Male
Donor age at sampling 48 yrs
Donor age of onset 28 yrs
Karyotype Normal
Reprogramming method Episomal vector
Induction method Monolayer & chemically defined medium
Size ≥1.5 million cells
Kit components 1 vial of Neural Stem Cells (≥1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL)
Cell type iPSC-derived neural stem cells
Growth properties Adherent
Mutation One allele of the huntingtin gene (HTT) has an expansion of 56 CAG repeats and the other allele has 15 CAG repeats.
Shipping conditions Dry ice
Storage conditions Liquid nitrogen