Human iPSC-Derived Renal Proximal Tubular Cells (male).
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iPSC-Derived Renal Proximal Tubular Cells are generated by the up-regulation of specific signalling pathways in Axol iPS cells, which result in the increased gene expression of kidney specific markers.
Gene expression profiling of Axol iPSC-Derived Renal Proximal Tubular Cells revealed that these cells express markers of renal proximal tubular cells such as GGT and CD13 and transporters OAT1, OAT3, OCT2, SGLT2 and PEPT1 at similar if not greater levels when compared to primary human renal proximal tubular cells. The expression of these genes are critical for functionality in applications such as toxicology studies where transporter mediated drug uptake and drug induced interleukin expression can be investigated.