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Human WNT-1

Human WNT-1

Product Code: ax135565 (10 µg) Categories: .

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Features & Benefits

Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors, and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. Wnt signaling induces and maintains the transformed phenotype, and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis, and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues.

Product Specification

Size 10µg
Purity Verified by SDS-PAGE and, where possible, by RP-HPLC
Shipping conditions Ambient temperature
Storage conditions See CoA shipped with product
Source E.coli
Endotoxin level < 0.1 ng/μg of protein (< 1 EU/μg)
Reconstitution See CoA shipped with product
Stability See CoA shipped with product