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Indirubin-3'-monoxime

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GSK-3b and CDK inhibitor CAS#: 160807-49-8 Citations: 1) Leclerc et al. (2001), Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem., 276 251 2) Damiens et al. (2001), Anti-mitotic properties of indirubin-3’-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene, 20 3786 3) Kim et al. (2011), Indirubin-3’-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem., 112 1384 4) Ding et al. (2010), Indirubin-3’-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease; Neurobiol. Dis., 39 156

Product Code: ax44045 (5 mg)

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Product Specification

Function / pharmacology A potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells2. Possesses antiangiogenic activity3. Attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease4. Cell permeable.
Chemical name 3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Molecular weight 277.29
Molecular formula C16H11N3O2
Physical description Dark red or brown solid
Solubility DMSO (6 mg/ml) Ethanol (4 mg/ml)
Size 5 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.