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GSK-3b and CDK inhibitor CAS#: 160807-49-8 Citations: 1) Leclerc et al. (2001), Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem., 276 251 2) Damiens et al. (2001), Anti-mitotic properties of indirubin-3’-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene, 20 3786 3) Kim et al. (2011), Indirubin-3’-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem., 112 1384 4) Ding et al. (2010), Indirubin-3’-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease; Neurobiol. Dis., 39 156
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