• Search


Please enquire for the latest availability and price information.

GSK-3b and CDK inhibitor CAS#: 160807-49-8 Citations: 1) Leclerc et al. (2001), Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?; J. Biol. Chem., 276 251 2) Damiens et al. (2001), Anti-mitotic properties of indirubin-3’-monoximine, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest; Oncogene, 20 3786 3) Kim et al. (2011), Indirubin-3’-monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis; J. Cell. Biochem., 112 1384 4) Ding et al. (2010), Indirubin-3’-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease; Neurobiol. Dis., 39 156

Product Code: ax44045 (5 mg)

Payment Options

We accept Visa and MasterCard in our online store.

Worldwide Shipping

We can get your purchases to you wherever you are.

Customer Care

As an Axol customer you have access to our support team and product specialists.

Product Specification

Function / pharmacology A potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells2. Possesses antiangiogenic activity3. Attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease4. Cell permeable.
Chemical name 3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Molecular weight 277.29
Molecular formula C16H11N3O2
Physical description Dark red or brown solid
Solubility DMSO (6 mg/ml) Ethanol (4 mg/ml)
Size 5 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.