Human Intra-Hepatic Biliary Epithelial Cells are cryopreserved after purification and provide a useful in vitro model for studying biliary cirrhosis and liver disease.
Human Intra-Hepatic Biliary Epithelial Cells line the intrahepatic biliary tree, a complex network of tubular conduits of different diameters within the liver. They comprise a very small amount (between 3 – 5%) of the total population of liver cells, yet produce as much as 40% of the daily output of bile. A number of studies have demonstrated that these cells play important roles in maintaining, modifying and augmenting the composition of canalicular bile by a coordinated series of hormone-regulated secretary and absorptive processes.
Intra-Hepatic Biliary Epithelial Cells also appear to have active immunologic roles in both innate and adaptive immune responses; the cells secrete chemokines and cytokines and serve to localize the immune response by expressing critical cell adhesion molecule. Under basal conditions, these cells are thought to be mitotically dormant. However, Intra-Hepatic Biliary Epithelial Cells proliferate markedly in response to a number of perturbations.