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Hedgehog pathway CAS#: 469-59-0 Citations: 1) Cooper et al. (1998), Teratogen-mediated inhibition of target tissue response to Shh signaling; Science, 280 1603 2) Mistretta et al. (2003), Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium; Dev. Biol., 254 1 3) Ghezale et al. (2013), Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect; Exp. Cell Res., 319 1043

Product Code: ax70709 (5 mg)

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Product Specification

Function / pharmacology Inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 μM). Binds directly to Smoothened (Smo)1. Inhibits the response of target tissues to Sonic hedgehog signaling2. Induces COX-2 overexpression in human erythroleukemia cells3.
Chemical name (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
Molecular weight 425.62
Molecular formula C27H39NO3
Physical description White solid
Solubility DMSO (5 mg/ml) DMF (6 mg/ml) Ethanol (20 mg/ml)
Size 5 mg
Stability Stable for 2 years as supplied. Solutions in DMSO, ethanol or DMF may be stored at -20°C for up to 3 months.