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Keratin 5 & 8

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification._x000B__x000B_Simple epithelia express cytokeratin 8 in combination with 18. Basal cells of stratified epithelia express cytokeratin 5 with cytokeratin 14. Therefore this antibody reacts with a wide range of epithelia and their carcinomas.

Product Code: ax1083061 (100 µg) Categories: .

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Product Specification

Application Western Blot|Immunohistochemistry (Frozen Sections)
Host Mouse
Size 100 µg
Species reactivity Human
Clone number C50
Isotype IgG1
Shipping conditions Ambient temperature
Storage conditions -20°C