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LYS6K2

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S6K inhibitor CAS#: 1082949-67-4 Citations: 1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 / 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

Product Code: ax42571 (5 mg)

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Product Specification

Function / pharmacology A selective inhibitor of the p70 ribosomal S6 kinase (S6K)1. Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM2. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K2. Cell permeable.
Chemical name 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
Molecular weight 445.42
Molecular formula C21H19F4N7
Physical description Yellow solid
Solubility DMSO (1 mg/ml) DMF (3 mg/ml)
Size 5 mg
Stability Stable for 3 years as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.