This antibody recognizes a protein of 45 kDa, identified as MEK1 (also known as ERK kinase 1, MAPK kinase 1, and MKK1). MEK1 is a member of a family of tyrosine/threonine protein kinases that activate the ERK1&2/MAPK enzymes by phosphorylating both the threonine and tyrosine residues of the threonine – glutamic acid – tyrosine (TEY) motif located within the activation loop. MEK1 shares approximately 80% homology with the closely related dual specificity protein kinase MEK2. Active Raf family members phosphorylate MEK1 at serines 218 and 222, thereby activating it. Serine 298 of MEK1 is phosphorylated by PAK proteins, which promotes MEK1 binding to c-Raf and its subsequent phosphorylation of MEK1, leading to activation of the MAPK pathway. This antibody also recognizes MEK2, but not MEK3.
We accept Visa and MasterCard in our online store.
We can get your purchases to you wherever you are.
As an Axol customer you have access to our support team and product specialists.