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This antibody recognizes a protein of 45 kDa, identified as MEK1 (also known as ERK kinase 1, MAPK kinase 1, and MKK1). MEK1 is a member of a family of tyrosine/threonine protein kinases that activate the ERK1&2/MAPK enzymes by phosphorylating both the threonine and tyrosine residues of the threonine – glutamic acid – tyrosine (TEY) motif located within the activation loop. MEK1 shares approximately 80% homology with the closely related dual specificity protein kinase MEK2. Active Raf family members phosphorylate MEK1 at serines 218 and 222, thereby activating it. Serine 298 of MEK1 is phosphorylated by PAK proteins, which promotes MEK1 binding to c-Raf and its subsequent phosphorylation of MEK1, leading to activation of the MAPK pathway. This antibody also recognizes MEK2, but not MEK3.

Product Code: ax1083589 (100 µg) Categories: .

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Product Specification

Application Western Blot|ELISA
Host Mouse
Size 100 µg
Species reactivity Human|Mouse|Rat
Clone number 263P15
Isotype IgG2a
Shipping conditions Ambient temperature
Storage conditions -20°C