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Mifepristone (RU486)

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Glucocorticoid antagonist CAS#: 84371-65-3 Citations: 1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses, Annu. Rev. Med. 48 129 / 2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins, J. Steroid Biochem. 31 161 / 3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor, Exp. Cell Res. 147 177

Product Code: ax134058 (100 mg)

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Product Specification

Function / pharmacology Mifepristone is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3.
Chemical name 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Molecular weight 429.59
Molecular formula C29H35NO2
Physical description Yellow solid
Solubility DMSO (40 mg/ml) Ethanol (20 mg/ml)
Size 100 mg
Stability Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.