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Mismatch Repair Protein 2 (MSH2)

Recognizes a ~102kDa identified as MSH2. Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites / simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.

Product Code: ax1083655 (500 µl) Categories: .

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Product Specification

Application Immunohistochemistry (Frozen & Paraffin Sections)
Host Mouse
Size 500 µL
Species reactivity Human
Clone number 2MSH01
Isotype IgG1
Shipping conditions Ambient temperature
Storage conditions -20°C