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Na Valproate

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HDAC inhibitor CAS#: 1069-66-5 Citations: 1) Phiel et al. (2001), Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen; J. Biol. Chem., 276 36734 2) 2) Kim et al. (2007), Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action; J. Pharmacol. Exp. Ther., 321 892 3) 3) Qing et al. (2008), Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer’s disease mouse models; J. Exp. Med., 205 2781

Product Code: ax133618 (5 g)

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Product Specification

Function / pharmacology Histone deacetylase inhibitor (IC50=400 M). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits A production and neuritic plaque formation in Alzheimer’s mouse models. Clinically useful anticonvulsant.
Chemical name 2-Propylpentanoic acid Na
Molecular weight 166.2
Molecular formula C8H15O2 Na
Physical description White solid
Solubility Water (50 mg/ml)
Size 5 gr
Stability Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months