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Okadaic acid

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protein phosphatase inhibitor CAS#: 78111-17-8 Citations: 1) Cohen et al. (1990), Okadaic acid: a new probe for the study of cellular regulation; Trends Biochem. Sci., 15 98 2) Hardie et al. (1991), Use of okadaic acid to inhibit protein phosphatases in intact cells; Clin. Methods Enzymol., 201 469 3) Haneji et al. (2013), Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells; J. Oncol., 42 1904 4) Standaert et al. (1999), Okadaic acid activates atypical protein kinase C (zeta/lambda) In rats and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport; J. Biol. Chem, 274 14074

Product Code: ax44925 (20 µg)

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Product Specification

Function / pharmacology A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation2. Induces apoptosis in a variety of cell types3. Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes4. Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.
Chemical name Isolated from marine dionflagellates
Molecular weight 805.0
Molecular formula C44H68O13
Physical description Off-white solid
Solubility DMSO (40 mg/ml) Ethanol (5 mg/ml)
Size 20 µg
Stability Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.